Retracing the path of evolution: polymorphisms of aspA codon 363 shape the fitness of Yersinia pestis

Emerging Microbes & Infections, 24 July 2025. Kai Song, Ruichen Lv, Leiming Shen, Yarong Wu, Xiuwei Qian, Yiming Cui, Yumeng Wei, Yanbing Li, Yanting Zhao, Wenwu Yao, Yafang Tan, Yanping Han, Yujing Bi, Zongmin Du, Florent Sebbane, Yujun Cui, Ruifu Yang, and Yajun Song. (Open Access.)

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Significance

This study reveals that a recurrent polymorphism at codon 363 of aspA shaped Yersinia pestis microevolution through a dynamic balance between gene inactivation and restoration, modulating bacterial fitness and interspecies competition.

Published July 24, 2025 9:00 AM - Last modified May 31, 2026 2:30 PM